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Βιολόγος Διευθύντρια Βιοχημικού Τμήματος

Τμήμα: Βιοχημικό

ΚΟΥΡΤΗ ΝΕΛΛΗ (ΑΝΑΣΤΑΣΙΑ ΕΛΛΗ)

Τομείς

Δημοσιεύσεις

Τίτλοι

Βιολόγος, PhD

Σπουδές - Προϋπηρεσία

  • 1976-1980: Πτυχίο Βιολογίας, Πανεπιστήμιο Αθηνών, βαθμός «άριστα»
  • 1981-1986: Διδακτορική Διατριβή, Βιολογικό Τμήμα, Πανεπιστήμιο Αθηνών, Τίτλος: “Μελέτη των ενζύμων μεταβολισμού του πολυ(Α) σε λεμφοκύτταρα ενεργοποιημένα με φυτοαιμοσυγκολλητίνη”, βαθμός «άριστα»
  • 1980-2005: Ερευνήτρια στο Τμήμα Βιοχημείας του Ερευνητικού Κέντρου «Γ. Παπανικολάου» του Νοσοκομείου «Ο ‘Αγιος Σάββας»
  • 1987-1988: Post-doc: Institut für Physiologische Chemie, Johannes Gutenberg Universität, Mainz (Prof. Mueller), Γερμανία
  • 2003-2004: Λέκτορας ΠΔ407/80: Μάθημα «Βιολογία», Ιατρική Σχολή, Δημοκρίτειο Πανεπιστήμιο Θράκης
  • 2005-2010: Υπεύθυνη στο Τμήμα Βιοχημείας και Μοριακής Βιολογίας του Ερευνητικού Κέντρου «Γ. Παπανικολάου» του Νοσοκομείου «Ο Άγιος Σάββας»
  • 2010-2019: Βιοχημικό Τμήμα του Νοσοκομείου «Ο Άγιος Σάββας»
  • 2019-: Διευθύντρια Βιοχημικού Τμήματος του Νοσοκομείου «Ο Άγιος Σάββας»

Μέλος σε Ιατρικούς Συλλόγους - Εταιρείες

Πανελλήνια Ένωση Βιολόγων
Ελληνική Εταιρεία Βιοχημείας και Μοριακής Βιολογίας
Ελληνική Εταιρία Κλινικής Χημείας-Κλινικής Βιοχημείας

Τομείς Ενδιαφέροντος

Κυριότερες Δημοσιεύσεις:

1. Tsiapalis, C.M., Ioannides, C., Trangas, T., Courtis, N., Pangalis, G.A., Cosmides, H.V., and Papamichail, M. (1982) Poly(A)-polymerase and poly(A)-nuclease levels in human leukemias. In Advances in comparative leukemia research (Yohn, D.S. and Blakeslee, J.R., Eds) Elsevier Biomedical, New York, pp.343-344

2. Tsiapalis, C.M., Trangas, T., Ioannides, C., Courtis, N., Pangalis, G.A., Cosmides, H.V., and Papamichail, M. (1983) Poly(A)-polymerase and poly(A)-nuclease levels in human acute and chronic leukemic cells. In Biochemical and biological markers of neoplastic transformation (Chandra P., Ed) Plenum Press, New York, pp.233-241

3. Papamichail, M., Trangas, T., Courtis, N., Ioannides, C., Cosmides, H.V., Pangalis, G.A., and Tsiapalis, C.M. (1983) Poly(A)-polymerase levels in leukemia. Haematol. Bluttrasfus. 28, 28-29

4. Trangas, T., Courtis, N., Pangalis, G.A., Cosmides, H.V., Ioannides, C., Papamichail, M. and Tsiapalis, C.M. (1984) Poly(adenylic acid) polymerase activity in normal and leukemic human lymphocytes. Cancer Res. 44, 3691-3697

5. Courtis, N., Trangas, T., and Tsiapalis, C.M. (1987) Increase in the levels of activity of polyadenylic acid metabolizing enzymes following phytohaemagglutinin stimulation of human lymphocytes. Mol. Cell. Biochem. 75, 33-42

6. Perez, S., Courtis, N., Kokkinopoulos, D., Papamichail, M., Tsiapalis, C.M. and Trangas, T. (1987) A colorimetric assay for the determination of 5’ nucleotidase activity. J. Immun. Meth. 101(1), 73-78

7. Tsiapalis, C.M., Trangas, T., Courtis, N., Gounaris, A., Kazazoglou, T., Garyfallides, S., and Havredaki, M. (1987) Molecular aspects of cell differentiation at the level of messenger polyadenylation-deadenylation. Prog. Clin. Biol. Res. 259, 27-39

8. Gounaris, A., Courtis, N., Pangalis, G.A., Tsiapalis, C.M., and Trangas, T. (1988) Relation between the activities of poly(A)-polymerase and the levels of protein synthesis in the lymphocytes of patients with chronic lymphocytic leukemia. Blut 57(5), 293-296

9. Trangas, T., Courtis, N., Gounaris, A., Papamichail, M., Kokkinopoulos, D., Perez, S., Tsiapalis, C.M., and Pangalis, G.A. (1989) Patterns of adenosine deaminase, ecto-5’-nucleotidase, poly(A)-polymerase and surface light chain expression in chronic lymphocytic leukemias. Blut 58(4), 187-193

10. Courtis, N., Trangas, T., Pangalis, G.A., and Tsiapalis, C.M.(1989) Correlation of poly(A)-polymerase and adenosine deaminase activity levels with effects of coformycin and 2’deoxycoformycin in cultured lymphocytes from patients with B- chronic lymphocytic leukemia. Clin. Chem. Enzym. Commun. 1, 171-175

11. Mueller, W.E.G., Wenger, R., Bachmann, M., Ugarcovic, D., Courtis, N., and Schroeder, H.C. (1989) Poly(A) metabolism and aging: a current view. Arch. Gerontol. Geriatr. 9(3), 231-250

12. Ioannides, P., Havredaki, M., Courtis, N., and Trangas, T. (1996) In vivo generation of 3’ and 5’ truncated species in the process of c-myc mRNA decay. Nucleic Acids Res. 24, 4969-4977

13. Scorilas, A., Courtis, N., Yotis, J., Talieri, M., Michailakis, M, and Trangas T. (1998) Poly(A)polymerase activity levels in breast tumor cytosols. J. Exp. Clin. Cancer Res. 17(4), 511-518

14. Ioannides, P., Courtis, N., Havredaki, M., Michailakis, M., Tsiapalis, C.M., and Trangas, T. (1999) The polyadenylation inhibitor cordycepin (3’dA) causes a decline in c-myc mRNA levels without affecting c-MYC protein levels. Oncogene 18(1), 117-125

15. Scorilas, A., Talieri, M., Ardavanis, A., Courtis, N., Yotis, J., Dimitriadis, E., Tsiapalis, C.M., and Trangas, T. (2000) Determination of Poly(A)polymerase Activity in Mammary Tumor Cytosols. A New Independent Prognostic Marker in Primary Breast Cancer. Cancer Research 60(19), 5427-5433

16. Samiotaki, M., Balatsos, N., Courtis, N., and Tsiapalis, C.M. (2000) Assignment of the 160 kDa subunit of Cleavage and Polyadenylation Specificity Factor (CPSF1) to human chromosome 8q24.23 by radiation hybrid mapping. Cytogenet. Cell Genet. 90, 234-5

17. Samiotaki, M., Balatsos, N., Courtis, N., and Tsiapalis, C.M. (2000) Assignment of the 100 kDa subunit of Cleavage and Polyadenylation Specificity Factor (CPSF2) to human chromosome 14q31.3 by radiation hybrid mapping. Cytogenet. Cell Genet. 90, 328-9

18. Lallas, G.C., Courtis, N., and Havredaki M. (2004) K562 cell sensitization to 5-fluorouracil or interferon-a induced apoptosis via cordycepin (3’-deoxyadenosine): fine control of cell apoptosis via poly(A) polymerase up-regulation. Int J Biol Markers 19(1), 58-66

19. Ioannidis, P., Kottaridi, C., Dimitriadis, E., Courtis, N., Mahaira, L.,Talieri, L.M., Giannopoulos, A., Iliadis, K., Papaioannou, D., Nasioulas, G., Trangas, T. (2004) Expression of the RNA-binding Protein CRD-BP in Brain and Non-Small Cell Lung Tumors. Cancer Lett 209(2), 245-50

20. Dimitriadis E, Trangas T, Milatos S, Foukas PG, Gioulbasanis I, Courtis N, Nielsen FC, Pandis N, Dafni U, Bardi G, Ioannidis P. (2007) Expression of oncofetal RNA binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer. Int J Cancer 121:486-94.

21. Rapti A, Trangas T, Samiotaki M, Ioannidis P, Dimitriadis E, Meristoudis C, Veletza S, Courtis N. (2010) The structure of the 5′-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation. Mol Cell Biochem 340(1-2):91-6

22. Meristoudis C, Trangas T, Lambrianidou A, Papadopoulos V, Dimitriadis E, Courtis N, Ioannidis (2015) Systematic analysis of the contribution of c-myc mRNA constituents upon cap and IRES mediated translation Biol Chem 396(12):1301-1